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Thalamocortical dysrhythmia : ウィキペディア英語版
Thalamocortical dysrhythmia
Thalamocortical Dysrhythmia (TCD) is a theoretical framework in which neuroscientists try to explain the positive and negative symptoms induced by neurological disorders like Parkinson's Disease, neurogenic pain, Tinnitus, Epilepsy as well as neuropsychiatric disorders like depression.
In TCD, normal thalamocortical resonance is disrupted by changes in the behaviour of neurons in the thalamus.
TCD can be treated with neurosurgical methods like the central lateral thalamotomy, which due to its invasiveness is only used on patients that have proven resistant to conventional therapies.
==Background==
At the base of the theory lies diminished excitatory or increased inhibitory input at the thalamic level. This leads to a switch of the thalamocortical neurons from tonic to burst firing and subsequently entrains thalamic and cortical areas with pathological oscillations at around 5 Hz.

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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